Kwalot (Brucea javanica (L.)

Description:
Tall shrubs, erect, very bitter, high 1-2,5 m. Odd pinnate leaf arrangement; child 5-13 leaves, most of the face, the child leaves, elongated oval-shaped lancet, pointed tip, serrated edge beringgit, base rounded or pointed, hairy 5,5-17,5 times 2-7,5 cm . Flowers 1 or 2 pairs, in order of long narrow panicle 2-30 cm. Petals of the flower jewelry; segment is very small petals, oval oval shape upside down, 0.75-1 mm. The crown has 5 petals, elongated shape, blunt, hair rarely, along the edge of berkelenjar, green and purple. Stamens as many as corolla, head of the essence no female flowers. Pistil rudimentary in male flowers, bertaju 4, at 2 pairs of flowers or female flowers and stems will fruit pistils 4, loose, bumps obvious thickening of the basic interest rate. Rounded stone fruit lengthwise, 8mm long. Flowering time from January to December. This plant can live in areas with 0,5-550 m altitude above sea level. More or less in 6 species of plants that grow in Africa. In Indonesia, many grown on Java and Madura, which is usually found in bushes, on the banks of the river, teak forests, young secondary forest, and as a hedge.
Curable Disease:
Brucea javanica seed extract effectively as amubisida. Brusein C Bruseantin and isolated from seed extract dissolved in n-butanol, the compound is active against Entamoeba histolytica. The potential is estimated for the inhibition of malaria parasite protein synthesis. In addition, Brucea javanica seed extract is active against Shigella Shiga, S. Boydii, Salmonella derby, Salmonella typhi type 11, Fibrio cholerae Inaba, Fibrio cholerae Ogawa. Brusatol isolated from the seeds was reported effective for treatment of dysentery. From the results of studies in vitro and in vivo is known that the fruit extracts have an effect as antiplasmodia makasar. In vitro bruseantin known that the existence of a positive effect on Plasmodim resistant falciparum klorokuin. Extract kwalot positive effect also found in Plasmodium berghei in vivo in experiments with mice. IC, of the nine types of compounds against Plasmodium falciparum kuasinoid K? 1 (resistant to klorokuin) on oral delivery ranges from 0.0046? 0.0008 mg / ml; four of nine active compounds tersebutjuga of Plasmodium berghei in vivo after delivery of oral. Effectiveness bruseolid found in Brucea javanica against Plasmodium berghei higher when compared klorokuin in in vivo experiments with mice. In addition, there is also found in cytotoxic activity of a class of insulation kuasinoid results from Brucea javanica. Antidisentri activity of fruit extracts clinical testing Bruceajavanica less effective when compared with emetin. In other types of Brucea which found that Brucea antidysentrica II? Hidroksikantin? 6? On and 1.11? Dimetoksikantin? 6? On the antitumor potential in vitro and in vivo. Also found that bruseanol C has antitumor potential of "human KB, A? 549 lung carcinoma in vitro") clinical pharmacology Fruit: fruit extract used in the treatment of dysentery amoeba. From the research note that the activities of Brucea fruit extracts antidisentri less effective when compared emetin with. Contra indication Fruit should not be used on children? children, pregnant women and women who had breast-feeding. dlinginkan not effect the external use of fruit was reported that some cases of anaphylaxis.

Utilization:
USE IN THE COMMUNITY

Traditional seeds are generally used in the treatment of various diseases including cancer, dysentery, malaria. Roots used to treat fever, dysentery, cough, rheumatism. Leaves used to treat fever, scabies, boils, centipede antidote. The fruit is used to reduce bleeding, dysentery. All parts of plants used in the treatment of fever, abdominal cramps, dysentery.
HOW TO USE IN THE COMMUNITY
For the treatment of amoebic dysentery from 7 to 10 fruit seeds kwalot made infusa with 110 mi water, drink 1 mi 100 times daily, repeated for 12 days.
For malaria treatment seven to ten kwalot fruit seeds, herbs Meniran 7 grams, 1 gram of bark pule and 110 mi water, made infusa; 1 times daily drink 100 ml; repeated for 14 days and for the maintenance of 1 times a month drink 100 ml.

Composition:
Seed bitter substances, triterpen, sterin, wax, phenolic compounds (tannin substances). Bitter substance found in seeds Brucea javanica L. Meer consists of bruseantin, bruseantinol, brusein A, B, C, D, dehidrobusein A, brusatol, yadanziolid, yadanziolid A, yadanziolid C, yadanziolid F, bitter compounds like cafeteria-6-on.